Return to fertility after removal of a levonorgestrel-releasing intrauterine device and Nova-T

Contraception. 1992 Dec;46(6):575-84. doi: 10.1016/0010-7824(92)90122-a.


In a European randomized multicenter study, the efficacy and safety of an intrauterine contraceptive device releasing 20 microgram levonorgestrel/24 hours (LNG-IUD) have been evaluated and compared to the Nova-T. Because the LNG-IUD has a strongly suppressive effect on the endometrium and in some women affects ovarian function, the return to fertility after removal of the IUD was studied. Two-hundred-nine women (71 in the Nova-T and 138 in the LNG-IUD group), who had their IUDs removed because of planning pregnancy, were followed at least 24 months or until termination of pregnancy. For the Nova-T, the cumulative conception gross rate was 71.2/100 women after 12 months (79.7 after 24 months) and for the LNG-IUD 79.1 (86.6 after 24 months). The difference between the devices is not statistically significant, and in spite of the endometrial suppression during use of LNG-IUD, there is no delay of return to fertility and in both groups 96% of the pregnancies occurred during the first year after removal of the device. Eighty-four % of the pregnancies in the Nova-T group and eighty-six % in the LNG-IUD group ended in live births. The results suggest that the endometrium recovers quickly, normal ovulations are established and the fertility seems to be unaffected after use of an LNG-IUD.

Publication types

  • Clinical Trial
  • Comparative Study
  • Multicenter Study
  • Randomized Controlled Trial

MeSH terms

  • Female
  • Fertility*
  • Fertilization
  • Follow-Up Studies
  • Humans
  • Intrauterine Devices, Copper* / adverse effects
  • Intrauterine Devices, Medicated* / adverse effects
  • Levonorgestrel*
  • Life Tables
  • Male
  • Pregnancy
  • Pregnancy Outcome*
  • Time Factors


  • Levonorgestrel