Pancytopenia related to azathioprine--an enzyme deficiency caused by a common genetic polymorphism: a review

J R Soc Med. 1992 Dec;85(12):752-6.
No abstract available

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Azathioprine / adverse effects*
  • Azathioprine / metabolism
  • Female
  • Humans
  • Methyltransferases / antagonists & inhibitors
  • Methyltransferases / deficiency*
  • Methyltransferases / metabolism
  • Middle Aged
  • Pancytopenia / chemically induced*
  • Pancytopenia / enzymology
  • Pancytopenia / genetics
  • Polymorphism, Genetic
  • Thioguanine / analogs & derivatives
  • Thioguanine / metabolism

Substances

  • 6-thioguainine disulfide
  • Methyltransferases
  • thiopurine methyltransferase
  • Thioguanine
  • Azathioprine