Pancytopenia related to azathioprine--an enzyme deficiency caused by a common genetic polymorphism: a review

J R Soc Med. 1992 Dec;85(12):752-6. doi: 10.1177/014107689208501213.

Authors

A Anstey¹, L Lennard, S C Mayou, J D Kirby

Affiliation

¹ Department of Dermatology, St Bartholomew's Hospital, West Smithfield, London.

No abstract available

Publication types

Case Reports
Research Support, Non-U.S. Gov't
Review

MeSH terms

Azathioprine / adverse effects*
Azathioprine / metabolism
Female
Humans
Methyltransferases / antagonists & inhibitors
Methyltransferases / deficiency*
Methyltransferases / metabolism
Middle Aged
Pancytopenia / chemically induced*
Pancytopenia / enzymology
Pancytopenia / genetics
Polymorphism, Genetic
Thioguanine / analogs & derivatives
Thioguanine / metabolism

Substances

6-thioguainine disulfide
Methyltransferases
thiopurine methyltransferase
Thioguanine
Azathioprine