Probing the Molecular Basis of Resistance to Pyrimethamine by Site-Directed Mutagenesis

J Med Chem. 1992 Jul 24;35(15):2912-5. doi: 10.1021/jm00093a026.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Binding Sites
  • Drug Resistance / genetics
  • Escherichia coli / drug effects
  • Escherichia coli / enzymology
  • Escherichia coli / genetics
  • Folic Acid Antagonists
  • Kinetics
  • Mutagenesis, Site-Directed*
  • Plasmodium / drug effects
  • Plasmodium / enzymology
  • Plasmodium / genetics
  • Pyrimethamine / pharmacology*
  • Tetrahydrofolate Dehydrogenase / genetics*
  • Thermodynamics

Substances

  • Folic Acid Antagonists
  • Tetrahydrofolate Dehydrogenase
  • Pyrimethamine