Laryngeal chondrosarcomas: a clinicopathologic study of 11 cases, including two "dedifferentiated" chondrosarcomas

Laryngoscope. 1992 Aug;102(8):858-67. doi: 10.1288/00005537-199208000-00004.


Laryngeal chondrosarcomas are uncommon, and those that contain a distinct, nonchondroid, high-grade spindle cell sarcoma (the so-called "dedifferentiated" chondrosarcoma or chondrosarcoma with additional malignant mesenchymal component [CAMMC]) are extremely rare. Laryngeal CAMMC merit special attention, as CAMMC in other sites portends a poor prognosis. Eleven patients with laryngeal chondrosarcomas are reported on; 2 of these patients had CAMMC. On follow-up, 3 of the 11 patients had recurrences. The first had recurrence 4 and 11 years after tumor enucleation; that patient died disease free 2 years after salvage total laryngectomy. The second had recurrence 2 years after partial laryngectomy and was lost to follow-up after salvage total laryngectomy. The last patient recurred 13 years after partial laryngectomy and underwent salvage total laryngectomy; that patient was one of the two who developed CAMMC, and he also developed stomal recurrence of the "dedifferentiated" component 3 years after total laryngectomy. The other 8 patients are disease free after partial laryngectomy (6) or total laryngectomy (2) 10 months to 12 years later (mean: 51 months). This includes the 1 other patient with CAMMC, who is disease free 60 months after total laryngectomy. Laryngeal CAMMC has been shown, in at least one of the two patients, to be associated with a poor outcome. Patients with recurrent laryngeal chondrosarcomas do not have a poorer outcome after salvage total laryngectomy. The authors advocate partial laryngectomy if technically feasible.

MeSH terms

  • Adult
  • Aged
  • Cell Transformation, Neoplastic / pathology
  • Chondrosarcoma / diagnostic imaging
  • Chondrosarcoma / pathology*
  • Chondrosarcoma / secondary
  • Chondrosarcoma / surgery
  • Female
  • Follow-Up Studies
  • Humans
  • Laryngeal Cartilages / diagnostic imaging
  • Laryngeal Cartilages / pathology
  • Laryngeal Cartilages / surgery
  • Laryngeal Neoplasms / diagnostic imaging
  • Laryngeal Neoplasms / pathology*
  • Laryngeal Neoplasms / surgery
  • Laryngectomy
  • Lymphatic Metastasis
  • Male
  • Mesoderm / pathology
  • Middle Aged
  • Radiography
  • S100 Proteins / analysis
  • Treatment Outcome


  • S100 Proteins