Acute uric acid nephropathy in pregnancy

Obstet Gynecol. 1992 Sep;80(3 Pt 2):488-9.


Background: Although uric acid clearance increases during gestation, uric acid nephropathy is a rare cause of acute renal failure in the pregnant woman.

Case: A 38-year-old woman experienced acute renal failure due to acute uric acid nephropathy at 30 weeks' gestation. The diagnosis was based on extreme hyperuricemia and an elevated uric acid-creatinine ratio. Treatment with forced diuresis, urine alkalinization, and mannitol infusion resulted in a prompt and complete recovery of renal function. The woman ultimately gave birth to a healthy child.

Conclusion: Acute uric acid nephropathy during pregnancy responds to conventional medical therapy.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Acute Kidney Injury / epidemiology
  • Acute Kidney Injury / etiology*
  • Adult
  • Female
  • Humans
  • Maternal Age
  • Pregnancy
  • Pregnancy Complications / epidemiology
  • Pregnancy Complications / etiology*
  • Pregnancy, High-Risk
  • Uric Acid / metabolism*


  • Uric Acid