Abstract
Studies on sevenless and bride of sevenless genes have revealed that the R8 cell plays a key role in the fate of the R7 photoreceptor cell, presenting on its surface an inductive cue to which R7 responds. sev-independent induction of R7 cells has been reported in the seven-up mutation, which appears to transform R1 and R6 cells to R7 cells. We have induced recessive mutations in a gene pokkuri (pok; pokkuri is a Japanese word that means "dropping dead") that lead to overproduction of R7 cells with rather minor effects on outer photoreceptors and R8 cells. Pok protein may function as a transcription factor, as the predicted amino acid sequence contains a region similar to the consensus established for the E-26-specific (Ets) domain.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Crosses, Genetic
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DNA-Binding Proteins*
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Drosophila / genetics*
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Drosophila / physiology
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Eye Proteins / genetics*
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Female
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Genes
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Genetic Carrier Screening
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Genotype
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Homozygote
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Humans
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Male
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Molecular Sequence Data
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Mosaicism
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Photoreceptor Cells / cytology
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Photoreceptor Cells / physiology*
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Protein-Tyrosine Kinases / genetics
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Proto-Oncogene Protein c-ets-2
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Proto-Oncogene Proteins / genetics*
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Proto-Oncogene Proteins c-ets
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Proto-Oncogenes*
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Repressor Proteins*
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Restriction Mapping
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Sequence Homology, Nucleic Acid
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Trans-Activators*
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Transcription Factors*
Substances
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DNA-Binding Proteins
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ERF protein, human
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ETS2 protein, human
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Eye Proteins
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Proto-Oncogene Protein c-ets-2
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Proto-Oncogene Proteins
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Proto-Oncogene Proteins c-ets
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Repressor Proteins
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Trans-Activators
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Transcription Factors
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Protein-Tyrosine Kinases