When Ras signaling reaches the mediator

Dev Cell. 2004 Feb;6(2):158-9. doi: 10.1016/s1534-5807(04)00029-2.


Numerous sequence-specific DNA binding proteins that couple extracellular stimuli to transcriptional regulation have been described. Less well understood is how these transcriptional regulators interact with the Mediator complex to initiate transcription and how those interactions are coordinated with the activation of signaling pathways. Recent work has begun to shed light on this important area of research.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • CCAAT-Enhancer-Binding Proteins / metabolism
  • DNA-Binding Proteins / metabolism
  • Gene Expression Regulation*
  • Genes, ras / physiology*
  • Models, Biological
  • Proto-Oncogene Proteins / metabolism
  • Signal Transduction / genetics
  • Signal Transduction / physiology*
  • Transcription Factor CHOP
  • Transcription Factors / metabolism*
  • Transcription, Genetic
  • Transcriptional Activation


  • CCAAT-Enhancer-Binding Proteins
  • DNA-Binding Proteins
  • Proto-Oncogene Proteins
  • Transcription Factors
  • Transcription Factor CHOP