Analysis, statistical validation and dissemination of large-scale proteomics datasets generated by tandem MS

Drug Discov Today. 2004 Feb 15;9(4):173-81. doi: 10.1016/S1359-6446(03)02978-7.


Tandem mass spectrometry has been used increasingly for high-throughput analysis of complex protein samples. A major challenge lies in the consistent, objective and transparent analysis of the large amounts of data generated by such experiments and in their dissemination and publication. Here, we review currently available computational tools and discuss the need for statistical criteria in the analysis of large proteomics datasets.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Databases, Factual
  • Humans
  • Mass Spectrometry / statistics & numerical data
  • Models, Statistical*
  • Proteomics / methods*
  • Proteomics / statistics & numerical data