Testicular cancer and occupational exposure to polyvinyl chloride plastics: a case-control study

Int J Cancer. 2004 Apr 10;109(3):425-9. doi: 10.1002/ijc.11709.


Exposure to polyvinyl chloride (PVC) plastics as a risk factor for testicular cancer was investigated. In total, 981 cases who were 20-75 years old and had reported to the Swedish Cancer Registry during 1993-1997 were included. One matched control from the population registry was used. Exposure was assessed by a questionnaire that was supplemented over the phone. Furthermore, an occupational hygienist qualified all exposures. In all, 791 matched pairs completed the questionnaire. Overall exposure to PVC plastics gave the odds ratio (OR)=1.35, 95% confidence interval (CI)=1.06-1.71, increasing with >10 year latency period to OR=1.45, 95% CI=1.06-1.98. No dose-response relationships were found but rather an inverse relationship with the highest odds ratios in the lowest exposure category. In conclusion, no clear association with testicular cancer and exposure to PVC could be found in our study in contrast to a previous observation.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Case-Control Studies
  • Humans
  • Male
  • Middle Aged
  • Occupational Diseases / etiology*
  • Occupational Exposure / adverse effects*
  • Polyvinyl Chloride / adverse effects*
  • Registries
  • Surveys and Questionnaires
  • Sweden / epidemiology
  • Testicular Neoplasms / chemically induced*


  • Polyvinyl Chloride