Synthesis of a new class of conformationally rigid phosphino-oxazolines: highly enantioselective ligands for Ir-catalyzed asymmetric hydrogenation

Duan Liu; Wenjun Tang; Xumu Zhang

doi:10.1021/ol0362717

Synthesis of a new class of conformationally rigid phosphino-oxazolines: highly enantioselective ligands for Ir-catalyzed asymmetric hydrogenation

Org Lett. 2004 Feb 19;6(4):513-6. doi: 10.1021/ol0362717.

Authors

Duan Liu¹, Wenjun Tang, Xumu Zhang

Affiliation

¹ Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.

PMID: 14961611
DOI: 10.1021/ol0362717

Abstract

[reaction: see text] A new class of conformationally rigid phosphino-oxazoline ligands were synthesized from readily available enantiopure phenyl glycinol. Ir complexes with these ligands are air-stable and highly enantioselective catalysts for asymmetric hydrogenation of aryl alkenes and alpha,beta-unsaturated esters in up to 99% ee.