Human CD4+ CD25+ Regulatory T Cells Control T-cell Responses to Human Immunodeficiency Virus and Cytomegalovirus Antigens

J Virol. 2004 Mar;78(5):2454-9. doi: 10.1128/jvi.78.5.2454-2459.2004.


Regulatory T (T(R)) cells maintain tolerance to self-antigens and control immune responses to alloantigens after organ transplantation. Here, we show that CD4(+) CD25(+) human T(R) cells suppress virus-specific T-cell responses. Depletion of T(R) cells from peripheral blood mononuclear cells enhances T-cell responses to cytomegalovirus and human immunodeficiency virus antigens. We propose that chronic viral infections lead to induction of suppressive T(R) cells that inhibit the antiviral immune response.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antigens, Viral / immunology*
  • CD4-Positive T-Lymphocytes / immunology*
  • CD4-Positive T-Lymphocytes / metabolism*
  • CD8-Positive T-Lymphocytes / immunology
  • CD8-Positive T-Lymphocytes / metabolism
  • Cells, Cultured
  • Cytomegalovirus / immunology*
  • Flow Cytometry
  • HIV / immunology*
  • Humans
  • Interferon-gamma / biosynthesis
  • Interferon-gamma / immunology
  • Lymphocyte Activation
  • Receptors, Interleukin-2 / metabolism*
  • Superantigens / immunology


  • Antigens, Viral
  • Receptors, Interleukin-2
  • Superantigens
  • Interferon-gamma