Abstract
Segregation and linkage analyse were performed on Problem 2 simulated data. Segregation analysis showed evidence for nearly recessive major susceptibility locus with parameter estimates close to the simulation input values. Linkage between this susceptibility locus (X) and the ten marker loci (A to J) led us to propose the following map: X-G-F-B.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Chromosome Mapping
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Chromosome Segregation / genetics*
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Computer Simulation*
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Genes, Recessive / genetics*
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Genetic Linkage
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Genetic Markers
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Genetic Predisposition to Disease / genetics*
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Humans
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Likelihood Functions
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Models, Genetic*
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Nuclear Family
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Odds Ratio
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Pedigree
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Penetrance
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Software