Eurycoma longifolia Jack enhances sexual motivation in middle-aged male mice

J Basic Clin Physiol Pharmacol. 2003;14(3):301-8. doi: 10.1515/jbcpp.2003.14.3.301.


Eurycoma longifolia Jack was investigated for sexual motivation activity in adult, middle-aged male mice and in retired breeders, using the modified open field and the modified runway choice methods. Each mouse received 500 mg/kg of one of 4 fractions of E. longifolia Jack, viz. chloroform, methanol, butanol, and water, whereas the mice in the control and yohimbine groups received 3 ml/kg of normal saline and 30 mg/kg of yohimbine daily respectively for 10 d. The results show a transient increase in the percentage of male mice responding to the right choice after chronic consumption of the fractions with 50 percent of the adult middle-aged male mice treated with E. longifolia Jack and yohimbine scoring the right choice after 8 and 5 days post-treatment respectively. In conclusion, this study has shown that E. longifolia Jack continues to enhance sexual motivation in adult, middle-aged male mice and in retired breeders.

MeSH terms

  • Administration, Oral
  • Aging*
  • Animals
  • Eurycoma / chemistry*
  • Male
  • Mice
  • Motivation*
  • Plant Extracts / pharmacology
  • Plant Roots / chemistry
  • Sexual Behavior, Animal / drug effects*
  • Yohimbine / pharmacology


  • Plant Extracts
  • Yohimbine