[Experience in the application of pramistar, a new nootropic preparation, in the treatment of memory disorders in patients with cerebrovascular pathology]

Lik Sprava. 2003 Dec;(8):67-72.
[Article in Russian]


Morbidity rise of cerebrovascular pathology is followed by remarkable cognitive decline. Chronic cerebral blood insufficiency and stroke consequences compose a group of the diseases which lead to different types of memory deterioration, consecutive memory decline and as a result to professional and social dysadaptation. The morphological basis of the problem consists in progressive structural cerebral deficit with forming a new adaptive system. The activity of this system is often not effective due to a lack of mediator supply. We have investigated the effects of monotherapy by a new nootropic drug--pramiracetam (Pramistar) on neuropsychological symptoms of memory deterioration in patients with chronic cerebrovascular insufficiency and stroke consequences in basilar and carotid vascular basin. The data obtained suggest statistically significant heterogeneous influence of the medicine on intensity of the evaluated symptoms.

Publication types

  • Comparative Study
  • Evaluation Study

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Basilar Artery / physiopathology
  • Carotid Arteries / physiopathology
  • Cerebrovascular Disorders / pathology*
  • Humans
  • Male
  • Memory Disorders / drug therapy*
  • Middle Aged
  • Nootropic Agents / therapeutic use*
  • Pyrrolidines / therapeutic use*
  • Treatment Outcome


  • Nootropic Agents
  • Pyrrolidines
  • pramiracetam