The contribution of epidermal growth factor receptor (EGFR) signaling pathway to radioresistance in human gliomas: a review of preclinical and correlative clinical data

Int J Radiat Oncol Biol Phys. 2004 Mar 1;58(3):927-31. doi: 10.1016/j.ijrobp.2003.09.092.


Purpose: The epidermal growth factor receptor (EGFR) pathway is frequently upregulated in high-grade gliomas via gene amplification and by specific mutations that render EGFR constitutively active (EGFRvIII).

Methods and materials: This review highlights EGFR's role in mediating radiation resistance in gliomas: underlying molecular mechanisms, with discussion of relevant preclinical and clinical correlative data.

Results: Preclinical and emerging clinical data suggest that EGFR signaling plays a potentially important role in mediating radiation resistance in human gliomas.

Conclusions: Targeting EGFR alone, or in combination with its downstream mediators, represents a promising new approach for the management of glioma patients.

Publication types

  • Review

MeSH terms

  • Animals
  • Brain Neoplasms / drug therapy
  • Brain Neoplasms / metabolism
  • Brain Neoplasms / radiotherapy*
  • Drug Resistance, Neoplasm / physiology
  • ErbB Receptors / physiology*
  • Glioma / drug therapy
  • Glioma / metabolism
  • Glioma / radiotherapy*
  • Humans
  • Neoplasm Proteins / physiology*
  • Neuroglia / physiology
  • Radiation Tolerance*
  • Signal Transduction / physiology*


  • Neoplasm Proteins
  • ErbB Receptors