Study design: Case report of a 31-year-old woman who presented with toxic myelopathy due to intrathecal administration of doxorubicin.
Objective: To describe the pathology and the rehabilitation of an uncommon complication of intrathecal drug administration during the oncologic treatment of acute lymphoma.
Setting: Spinal cord rehabilitation center, University Hospital.
Method: Clinical and radiological observations during a rehabilitation program.
Results: Evidence of neurological improvement and rehabilitation potential after severe myelopathy due to intrathecal injection of doxorubicin.
Conclusion: This is, to our knowledge, the first report of severe myelopathy following accidental intrathecal administration of doxorubicin. Despite early complete paraplegia, some neurological and functional recovery was observed.