Chronic granulomatous disease is a little common primary immunodeficiency affecting innate immune system. This article presents the case of an 8-year-old female patient whose disease started at three months of age with respiratory ways' infections. When she was two years old, she suffered another presentation of right basal pneumonia and right cervical mass, whose biopsy reported childhood chronic granulomatous disease. At eight years old, patient suffered bacteraemia due to Salmonella group D, thus patient started prophylaxis with trimethoprim-sulfamethoxazole and, to date, she has continued stable.