Autoantibodies in early arthritis: advances in diagnosis and prognostication

Clin Exp Rheumatol. Sep-Oct 2003;21(5 Suppl 31):S59-64.

Abstract

Several excellent reviews have recently been published on the significance of autoantibodies in rheumatoid arthritis (RA) (1-4). Here we: (i) review selected longitudinal studies examining the predictive utility of autoantibodies in early arthritis and early RA cohorts; (ii) assess the relevance of autoantibodies as an independent parameter for prediction and prognostication of RA; and (iii) describe the potential of multiplex autoantibody assays, including miniaturized, high-throughput microarray technology, to improve diagnosis and prognostication in recent-onset synovitis/early arthritis patients.

Publication types

  • Review

MeSH terms

  • Adult
  • Aged
  • Arthritis, Rheumatoid / diagnosis*
  • Arthritis, Rheumatoid / immunology*
  • Autoantibodies / analysis
  • Autoantibodies / immunology
  • Biomarkers / analysis
  • Disease Progression
  • Female
  • Humans
  • Male
  • Middle Aged
  • Predictive Value of Tests
  • Prognosis
  • Rheumatoid Factor / analysis
  • Rheumatoid Factor / immunology*
  • Risk Assessment
  • Sensitivity and Specificity
  • Severity of Illness Index
  • Synovial Fluid / chemistry
  • Time Factors

Substances

  • Autoantibodies
  • Biomarkers
  • Rheumatoid Factor