Extracts of Phellinus linteus grown on germinated brown rice suppress liver damage induced by carbon tetrachloride in rats

Biotechnol Lett. 2003 Dec;25(24):2093-6. doi: 10.1023/b:bile.0000007071.28105.c1.

Abstract

Extracts of Phellinus linteus (EPB), grown on germinated brown rice, protected rats from liver injury induced by carbon tetrachloride (CCl4). Peroxidation products in the liver were decreased to 10% by EPB. Catalase and superoxide dismutase activities were significantly decreased to 55% and 39% by CCl4 administration, but EPB blocked this effect, resulting in enzyme activities at control levels. Expression of cytochromeP450 2E1 (CYP2E1) protein was significantly decreased to 88% in CCl4-treated rats but remained at control levels when EPB was also administered. EPB did not affect the altered fatty acid composition induced by CCl4. The hepatoprotective effect of EPB may be mediated by EPB's prevention of CCl4-induced CYP2E1 degradation.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antioxidants / administration & dosage
  • Basidiomycota / growth & development
  • Basidiomycota / isolation & purification*
  • Carbon Tetrachloride
  • Cell Extracts / administration & dosage*
  • Chemical and Drug Induced Liver Injury
  • Cytochrome P-450 CYP2E1 / metabolism*
  • Fatty Acids / metabolism*
  • Injections, Intraperitoneal
  • Lipid Peroxidation / drug effects
  • Liver Diseases / diagnosis
  • Liver Diseases / drug therapy*
  • Liver Diseases / metabolism*
  • Male
  • Medicine, East Asian Traditional
  • Oryza / microbiology*
  • Probiotics / administration & dosage
  • Rats
  • Rats, Sprague-Dawley
  • Treatment Outcome

Substances

  • Antioxidants
  • Cell Extracts
  • Fatty Acids
  • Carbon Tetrachloride
  • Cytochrome P-450 CYP2E1