Design considerations for efficient and effective microarray studies

Biometrics. 2003 Dec;59(4):822-8. doi: 10.1111/j.0006-341x.2003.00096.x.


This article describes the theoretical and practical issues in experimental design for gene expression microarrays. Specifically, this article 1) discusses the basic principles of design (randomization, replication, and blocking) as they pertain to microarrays, and 2) provides some general guidelines for statisticians designing microarray studies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biometry / methods
  • Humans
  • Models, Genetic
  • Models, Statistical
  • Observer Variation
  • Oligonucleotide Array Sequence Analysis / methods*
  • RNA / genetics
  • Reproducibility of Results
  • Research Design


  • RNA