Objective: To investigate the pharmacokinetics of honokiol in rats.
Methods: Honokiol injection was delivered by vein injection to SD-rats. The blood samples were gathered at a series of time lags. Honokiol in rat plasma was determined with an RP-HPLC method and the data were analyzed with program 3P87.
Results: After i.v. injection of honokiol, concentration-time curves were fitted to a 3-compartment model: with halftime of 2.8 min, 11.9 min, and 56.8 min.
Conclusion: Honokiol was quickly distributed in rats after i.v. and the concentration decreased rapidly. Our studies provided important referrence to the research on the pharmacodynamics and the pharmaceutics of Honokiol.