Urethral pressure response to alpha-adrenergic agonist and antagonist drugs in anesthetized healthy male cats

Am J Vet Res. 1992 Jul;53(7):1161-5.


Urethral smooth muscle tone in response to treatment with phenylephrine, a selective alpha 1-adrenergic receptor agonist, and prazosin a selective alpha 1-adrenergic receptor antagonist, was evaluated in 12 anesthetized healthy adult sexually intact male cats. Intravenous administration of prazosin (20 to 30 micrograms/kg of body weight) decreased the average preprostatic and prostatic intraurethral pressure, compared with baseline and postphenylephrine (20 to 30 micrograms/kg) administration, values. Neither prazosin nor phenylephrine administration had an effect on functional urethral length. Results have implications for the pharmacologic management of lower urinary tract disorders in male cats.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analysis of Variance
  • Anesthesia, General / veterinary
  • Animals
  • Cats / physiology*
  • Heart Rate / drug effects
  • Injections, Intravenous / veterinary
  • Male
  • Muscle, Smooth / drug effects
  • Muscle, Smooth / physiology
  • Phenylephrine / administration & dosage
  • Phenylephrine / pharmacology*
  • Prazosin / administration & dosage
  • Prazosin / pharmacology*
  • Pressure
  • Urethra / drug effects*
  • Urethra / physiology


  • Phenylephrine
  • Prazosin