Pathology: cancer cells compress intratumour vessels

Nature. 2004 Feb 19;427(6976):695. doi: 10.1038/427695a.


The delivery of therapeutic drugs to solid tumours may be impaired by structural and functional abnormalities in blood and lymphatic vessels. Here we provide evidence that proliferating cancer cells cause intratumour vessels to compress and collapse. By reducing this compressive mechanical force and opening vessels, cytotoxic cancer treatments have the potential to increase blood perfusion, thereby improving drug delivery.

MeSH terms

  • Animals
  • Cell Division
  • Diphtheria Toxin / pharmacology*
  • Humans
  • Mice
  • Neoplasm Transplantation
  • Neoplasms / blood supply*
  • Neoplasms / drug therapy*
  • Neoplasms / pathology
  • Reperfusion*
  • Transplantation, Heterologous


  • Diphtheria Toxin