Osteoporosis: The dynamic relationship between magnesium and bone mineral density in the heart transplant patient

Crit Care Nurs Q. Jan-Mar 2004;27(1):96-100. doi: 10.1097/00002727-200401000-00010.


Osteoporosis is a common, and potentially severe, complication seen in the heart transplant recipient. Frequently there is loss of bone mineral density prior to transplant that begins the downward spiral to fractures of the femoral neck and vertebrae. Multiple factors are responsible for the development of osteoporosis posttransplant. These factors include pretransplant bone mineral loss, use of corticosteroids and cyclosporine posttransplant, and development of persistent hypomagnesemia posttransplant. This article explores the relationship of serum magnesium levels to maintenance of bone mineral density.

Publication types

  • Review

MeSH terms

  • Absorptiometry, Photon
  • Bone Density*
  • Bone and Bones / metabolism
  • Heart Transplantation / adverse effects*
  • Heart Transplantation / immunology
  • Humans
  • Immunosuppressive Agents / adverse effects
  • Magnesium / physiology*
  • Magnesium Deficiency / diagnosis
  • Magnesium Deficiency / etiology*
  • Magnesium Deficiency / metabolism
  • Magnesium Deficiency / therapy
  • Osteoporosis / diagnosis
  • Osteoporosis / etiology*
  • Osteoporosis / metabolism
  • Osteoporosis / therapy
  • Primary Prevention / methods
  • Risk Factors
  • Transplantation Immunology


  • Immunosuppressive Agents
  • Magnesium