Lack of prognostic value of histopathologic parameters in Hodgkin's disease, nodular sclerosis type. A study of 123 patients with limited stage disease who had undergone laparotomy and were treated with radiation therapy

Arch Pathol Lab Med. 1992 Aug;116(8):856-61.


The value of histopathologic parameters in predicting the long-term overall survival probabilities was studied in a series of 123 patients with pathologic stage IA, IB, IIA, IIB, or IIIA Hodgkin's disease, nodular sclerosis type who were treated with curative radiation therapy. The parameters that were studied included the relative proportion of atypical vs reactive cells, amount of eosinophils, presence of necrosis, degree of mitotic activity, intensity of different types of mesenchymal reactions, classification in three subtypes (ie, lymphocyte predominance, mixed cellularity, and lymphocyte depletion) or in two grades (ie, grades 1 and 2), and identification of the syncytial variant. For each parameter, the association with clinical risk factors was also analyzed. The results of this study show that there are no pathologic features that carry a significant predictive value of the overall survival.

MeSH terms

  • Adolescent
  • Adult
  • Combined Modality Therapy
  • Female
  • Hodgkin Disease / pathology*
  • Hodgkin Disease / radiotherapy
  • Hodgkin Disease / surgery
  • Humans
  • Laparotomy
  • Lymphocytes / pathology
  • Male
  • Middle Aged
  • Mitotic Index
  • Necrosis
  • Prognosis
  • Sclerosis
  • Statistics as Topic