Decreased blood levels of lactic acid and urinary excretion of 3-methylhistidine after exercise by chronic taurine treatment in rats

J Nutr Sci Vitaminol (Tokyo). 2003 Dec;49(6):375-80. doi: 10.3177/jnsv.49.375.


Taurine is reported to increase contractility of skeletal muscle and cardiac myocyte, which can increase exercise performance. The present study aimed to clarify taurine's effect on chronic endurance exercise, especially accumulation of lactic acid (LA), a marker of fatigue and ability of aerobic exercise, and urinary secretion of 3-methylhistidine (3-MH), a marker of muscle breakdown in rats. After exercise blood levels of LA and urinary excretion of 3-MH were significantly increased and this increase was significantly less in those with chronic treatment of taurine. Taurine treatment also significantly decreased fat accumulation and blood levels of cholesterol and triglyceride, which might improve insulin resistance and utilization of fat and glucose. These results indicate taurine treatment is useful for reducing physical fatigue and muscle damage during exercise training in rats, presumably due to antioxidant property and improvement of muscle and cardiac functions by taurine.

MeSH terms

  • Animals
  • Blood Glucose / analysis
  • Blood Proteins / analysis
  • Body Weight
  • Cholesterol / blood
  • Creatinine / blood
  • Cysteine / blood
  • Dietary Supplements
  • Eating
  • Fatty Acids, Nonesterified / blood
  • Lactic Acid / blood*
  • Male
  • Methylhistidines / urine*
  • Physical Exertion*
  • Rats
  • Rats, Wistar
  • Taurine / pharmacology*
  • Triglycerides / blood


  • Blood Glucose
  • Blood Proteins
  • Fatty Acids, Nonesterified
  • Methylhistidines
  • Triglycerides
  • Taurine
  • Lactic Acid
  • Cholesterol
  • Creatinine
  • Cysteine
  • 3-methylhistidine