Strategy and model building in the fourth dimension: a null model for genotype x age interaction as a Gaussian stationary stochastic process

BMC Genet. 2003 Dec 31;4 Suppl 1(Suppl 1):S34. doi: 10.1186/1471-2156-4-S1-S34.


Background: Using univariate and multivariate variance components linkage analysis methods, we studied possible genotype x age interaction in cardiovascular phenotypes related to the aging process from the Framingham Heart Study.

Results: We found evidence for genotype x age interaction for fasting glucose and systolic blood pressure.

Conclusions: There is polygenic genotype x age interaction for fasting glucose and systolic blood pressure and quantitative trait locus x age interaction for a linkage signal for systolic blood pressure phenotypes located on chromosome 17 at 67 cM.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Adult Children
  • Aged
  • Aging / genetics*
  • Aging / physiology
  • Blood Glucose / genetics
  • Blood Glucose / physiology
  • Blood Pressure / genetics
  • Cardiovascular System / chemistry
  • Cardiovascular System / metabolism
  • Cohort Studies
  • Fasting / blood
  • Female
  • Genetic Linkage / genetics
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Models, Statistical*
  • Multifactorial Inheritance / genetics
  • Normal Distribution
  • Quantitative Trait Loci / genetics
  • Quantitative Trait, Heritable
  • Stochastic Processes
  • Systole


  • Blood Glucose