Usefulness of anti-GQ1b IgG antibody testing in Fisher syndrome compared with cerebrospinal fluid examination

J Neuroimmunol. 2004 Mar;148(1-2):200-5. doi: 10.1016/j.jneuroim.2003.11.017.

Abstract

Fisher syndrome (FS), a variant of Guillain-Barré syndrome (GBS), is a rare disorder, and there are few reported studies of a large number of patients with FS. Cerebrospinal fluid (CSF) albuminocytological dissociation was found in 59% of 123 FS patients during the first 3 weeks of illness, while serum anti-GQ1b IgG antibody was positive in 85%. Whereas the incidence of CSF albuminocytological dissociation increased from the first to second weeks in FS, anti-GQ1b IgG antibody peaked in the first week, but there was no CSF albuminocytological dissociation. Statistically, anti-GQ1b antibody testing was superior to a CSF examination in supporting a diagnosis of FS during the first 3 weeks of illness, especially in the first week.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Albumins / cerebrospinal fluid
  • Analysis of Variance
  • Antibodies, Anti-Idiotypic / blood
  • Antibodies, Anti-Idiotypic / cerebrospinal fluid
  • Antibodies, Anti-Idiotypic / immunology
  • Child
  • Child, Preschool
  • Female
  • Gangliosides / immunology*
  • Guillain-Barre Syndrome / blood
  • Guillain-Barre Syndrome / cerebrospinal fluid
  • Guillain-Barre Syndrome / diagnosis
  • Guillain-Barre Syndrome / immunology
  • Humans
  • Immunoglobulin G / blood*
  • Infant
  • Infant, Newborn
  • Male
  • Middle Aged
  • Miller Fisher Syndrome / blood
  • Miller Fisher Syndrome / cerebrospinal fluid
  • Miller Fisher Syndrome / diagnosis*
  • Miller Fisher Syndrome / immunology
  • Statistics, Nonparametric
  • Time Factors

Substances

  • Albumins
  • Antibodies, Anti-Idiotypic
  • Gangliosides
  • Immunoglobulin G
  • GQ1b ganglioside