Myosin-1c, the hair cell's adaptation motor

Annu Rev Physiol. 2004;66:521-45. doi: 10.1146/annurev.physiol.66.032102.112842.


Given their prominent actin-rich subcellular specializations, it is no surprise that mechanosensitive hair cells of the inner ear exploit myosin molecules-the only known actin-dependent molecular motors-to carry out exotic but essential tasks. Recent experiments have confirmed that an unconventional myosin isozyme, myosin-1c, is a component of the hair cell's adaptation-motor complex. This complex carries out slow adaptation, provides tension to sensitize transduction channels, and may participate in assembly of the transduction apparatus. This review focuses on the detailed operation of the adaptation motor and the functional consequences of the incorporation of this specific myosin isozyme into the motor complex.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adaptation, Physiological / physiology*
  • Animals
  • Cell Movement / physiology
  • Hair Cells, Auditory / physiology*
  • Humans
  • Mechanotransduction, Cellular / physiology
  • Myosin Type I
  • Myosins / chemistry
  • Myosins / physiology*
  • Structure-Activity Relationship


  • Myosin Type I
  • MYO1C protein, human
  • Myosins