Transverse Myelitis: pathogenesis, diagnosis and treatment

Front Biosci. 2004 May 1;9:1483-99. doi: 10.2741/1351.


Transverse Myelitis (TM) is a clinical syndrome in which an immune-mediated process causes neural injury to the spinal cord, resulting in varying degrees of weakness, sensory alterations and autonomic dysfunction. TM may exist as part of a multi-focal CNS disease (e.g. MS), multi-systemic disease (e.g. systemic lupus erythematosus), or as an isolated, idiopathic entity. In this article, we will summarize recent classification and diagnostic schemes (1), which provide a framework for the acute management of patients with TM. Additionally, we will review current concepts on the natural history, immunopathogenesis and treatment strategies for patients with TM.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Humans
  • Myelitis, Transverse* / diagnosis
  • Myelitis, Transverse* / immunology
  • Myelitis, Transverse* / therapy
  • Nervous System Diseases / immunology
  • Terminology as Topic