Diagnostic considerations in juvenile parkinsonism

Mov Disord. 2004 Feb;19(2):123-35. doi: 10.1002/mds.10644.

Abstract

Juvenile parkinsonism (JP) describes patients in whom the clinical features of parkinsonism manifest before 21 years of age. Many reported cases that had a good response to levodopa have proved to have autosomal recessive juvenile parkinsonism (AR-JP) due to mutations in the parkin gene. With the exception of parkin mutations and dopa-responsive dystonia, most causes are associated with the presence of additional neurological signs, resulting from additional lesions outside of the basal ganglia. Lewy body pathology has only been reported in one case, suggesting that a juvenile form of idiopathic Parkinson's disease may be extremely rare.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adolescent
  • Adult
  • Brain / pathology
  • Chromosome Aberrations
  • Genes, Recessive / genetics
  • Humans
  • Lewy Bodies / pathology
  • Mutation / genetics
  • Neurologic Examination
  • Parkinson Disease / diagnosis
  • Parkinson Disease / genetics
  • Parkinson Disease / pathology
  • Parkinsonian Disorders / diagnosis*
  • Parkinsonian Disorders / genetics
  • Parkinsonian Disorders / pathology
  • Ubiquitin-Protein Ligases / genetics

Substances

  • Ubiquitin-Protein Ligases
  • parkin protein