Parkinson's disease patients with bilateral subthalamic deep brain stimulation gain weight

Mov Disord. 2004 Feb;19(2):206-12. doi: 10.1002/mds.10630.


Weight, body mass index (BMI) and energy expenditure/energy intake (EE/EI) was studied in 19 Parkinson's disease (PD) patients after subthalamic deep brain stimulation (STN-DBS) versus 14 nonoperated ones. Operated patients had a significant weight gain (WG, + 9.7 +/- 7 kg) and BMI increase (+ 4.7 kg/m2). The fat mass was higher after STN-DBS. Resting EE (REE; offdrug/ON stimulation) was significantly decreased in STN-DBS patients, while their daily energy expenditure (DEI) was not significantly different. A significant correlation was found among WG, BMI increase, and pre-operative levodopa-equivalent daily dose, their reduction after STN-DBS, and the differential REE related to stimulation and the REE in the offdrug/OFF stimulation condition. In conclusion, STN-DBS in PD induces a significant WG associated with a reduction in REE without DEI adjustment.

Publication types

  • Comparative Study

MeSH terms

  • Aged
  • Antiparkinson Agents / administration & dosage
  • Antiparkinson Agents / adverse effects
  • Body Composition / physiology
  • Body Mass Index
  • Combined Modality Therapy
  • Dominance, Cerebral / physiology*
  • Dyskinesia, Drug-Induced / physiopathology
  • Dyskinesia, Drug-Induced / therapy
  • Electric Stimulation Therapy / adverse effects*
  • Energy Metabolism / physiology
  • Female
  • Follow-Up Studies
  • Humans
  • Levodopa / administration & dosage
  • Levodopa / adverse effects
  • Male
  • Middle Aged
  • Parkinson Disease / physiopathology
  • Parkinson Disease / therapy*
  • Prospective Studies
  • Subthalamic Nucleus / physiopathology*
  • Treatment Outcome
  • Weight Gain / physiology*


  • Antiparkinson Agents
  • Levodopa