Abstract
Significantly increased plasma total homocysteine levels (t-Hcys) appeared in treated Huntington disease (HD) patients compared to controls and untreated HD subjects. Because the protein Huntingtin interacts with the homocysteine metabolism modulating enzyme cystathionine beta-synthase, we hypothesize that homocysteine promotes neurodegeneration in HD.
MeSH terms
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Adult
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Biomarkers / blood
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Central Nervous System Agents / administration & dosage*
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Central Nervous System Agents / adverse effects
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Central Nervous System Agents / pharmacokinetics
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Disease Progression
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Drug Interactions
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Female
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Homocysteine / blood*
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Humans
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Huntingtin Protein
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Huntington Disease / blood
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Huntington Disease / diagnosis
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Huntington Disease / drug therapy*
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Hyperhomocysteinemia / blood*
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Hyperhomocysteinemia / diagnosis
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Male
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Metabolic Clearance Rate / drug effects
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Middle Aged
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Mutation / genetics
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Nerve Tissue Proteins / genetics
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Neurologic Examination
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Nuclear Proteins / genetics
Substances
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Biomarkers
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Central Nervous System Agents
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HTT protein, human
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Huntingtin Protein
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Nerve Tissue Proteins
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Nuclear Proteins
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Homocysteine