The kiss of death

Neuron. 2004 Feb 19;41(4):491-3. doi: 10.1016/s0896-6273(04)00079-0.


The programmed cell death (PCD) of neurons is generally thought to be cell autonomous and not to require a death signal from other cells. A recent study by Marín-Teva et al., in this issue of Neuron, brings this theory into question and suggests that neighboring microglia actively participate in the PCD of Purkinje cells in the cerebellum.

Publication types

  • Comment
  • News

MeSH terms

  • Animals
  • Apoptosis / physiology*
  • Caspases / metabolism
  • Cell Communication / physiology*
  • Membrane Lipids / metabolism
  • Microglia / physiology*
  • Purkinje Cells / physiology*
  • Signal Transduction / physiology*


  • Membrane Lipids
  • Caspases