Tumor necrosis factor: an apoptosis JuNKie?

Cell. 2004 Feb 20;116(4):491-7. doi: 10.1016/s0092-8674(04)00166-7.

Abstract

TNF's main function is to stimulate inflammation by turning on gene transcription through the IKK/NFkappaB and JNK/AP-1 signaling cascades. TNF also can trigger apoptosis through caspase-8, but the role and underlying mechanism of this activity are not fully understood. Here, we review recent data on the role of JNK in the regulation of TNF-dependent apoptosis and discuss what is known so far about how cells decide whether to live or die in response to TNF.

Publication types

  • Review

MeSH terms

  • Animals
  • Apoptosis*
  • Caspase 8
  • Caspases / metabolism
  • Drosophila
  • Drosophila Proteins
  • Gene Expression Regulation
  • Humans
  • I-kappa B Kinase
  • Inflammation
  • JNK Mitogen-Activated Protein Kinases*
  • MAP Kinase Kinase 4
  • Mitogen-Activated Protein Kinase Kinases / metabolism*
  • Models, Biological
  • Phosphorylation
  • Protein-Serine-Threonine Kinases / metabolism
  • Signal Transduction
  • Transcription, Genetic
  • Tumor Necrosis Factor-alpha / metabolism
  • Tumor Necrosis Factor-alpha / physiology*

Substances

  • Drosophila Proteins
  • Tumor Necrosis Factor-alpha
  • Protein-Serine-Threonine Kinases
  • CHUK protein, human
  • I-kappa B Kinase
  • IKBKB protein, human
  • IKBKE protein, human
  • IKKbeta protein, Drosophila
  • JNK Mitogen-Activated Protein Kinases
  • MAP Kinase Kinase 4
  • Mitogen-Activated Protein Kinase Kinases
  • CASP8 protein, human
  • Caspase 8
  • Caspases