Abstract
TNF's main function is to stimulate inflammation by turning on gene transcription through the IKK/NFkappaB and JNK/AP-1 signaling cascades. TNF also can trigger apoptosis through caspase-8, but the role and underlying mechanism of this activity are not fully understood. Here, we review recent data on the role of JNK in the regulation of TNF-dependent apoptosis and discuss what is known so far about how cells decide whether to live or die in response to TNF.
MeSH terms
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Animals
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Apoptosis*
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Caspase 8
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Caspases / metabolism
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Drosophila
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Drosophila Proteins
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Gene Expression Regulation
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Humans
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I-kappa B Kinase
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Inflammation
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JNK Mitogen-Activated Protein Kinases*
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MAP Kinase Kinase 4
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Mitogen-Activated Protein Kinase Kinases / metabolism*
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Models, Biological
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Phosphorylation
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Protein-Serine-Threonine Kinases / metabolism
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Signal Transduction
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Transcription, Genetic
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Tumor Necrosis Factor-alpha / metabolism
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Tumor Necrosis Factor-alpha / physiology*
Substances
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Drosophila Proteins
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Tumor Necrosis Factor-alpha
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Protein-Serine-Threonine Kinases
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CHUK protein, human
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I-kappa B Kinase
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IKBKB protein, human
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IKBKE protein, human
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IKKbeta protein, Drosophila
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JNK Mitogen-Activated Protein Kinases
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MAP Kinase Kinase 4
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Mitogen-Activated Protein Kinase Kinases
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CASP8 protein, human
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Caspase 8
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Caspases