Design, synthesis and evaluation of novel 1,4-naphthoquinone derivatives as antifungal and anticancer agents

Vishnu K Tandon; Rakeshwar B Chhor; Ravindra V Singh; Sanjay Rai; Dharmendra B Yadav

doi:10.1016/j.bmcl.2004.01.002

Design, synthesis and evaluation of novel 1,4-naphthoquinone derivatives as antifungal and anticancer agents

Bioorg Med Chem Lett. 2004 Mar 8;14(5):1079-83. doi: 10.1016/j.bmcl.2004.01.002.

Authors

Vishnu K Tandon¹, Rakeshwar B Chhor, Ravindra V Singh, Sanjay Rai, Dharmendra B Yadav

Affiliation

¹ Department of Chemistry, Lucknow University, Lucknow-226001, U. P., India. vishnutandon@rediffmail.com

PMID: 14980639
DOI: 10.1016/j.bmcl.2004.01.002

Abstract

A series of 1,4-naphthoquinone derivatives were synthesized and tested for antifungal and antitumor activity against a number of fungal disease causative species and Walker 256 carcinoma cell lines. The results show that the compounds 8a,e and 11b possess pronounced antifungal profile where as 7b and f were found to be active against Walker 256 carcinoma cell lines. Moreover 7c and 11a showed inhibitory effect against reverse transcriptase enzyme from Rauscher Murine Leukemia Virus.

MeSH terms

Animals
Antifungal Agents / chemical synthesis
Antifungal Agents / pharmacology*
Antineoplastic Agents / chemical synthesis
Antineoplastic Agents / pharmacology*
Carcinoma 256, Walker
Drug Design
Drug Evaluation, Preclinical / methods
Microbial Sensitivity Tests / statistics & numerical data
Naphthoquinones / chemical synthesis
Naphthoquinones / pharmacology*

Substances

Antifungal Agents
Antineoplastic Agents
Naphthoquinones
1,4-naphthoquinone