Side-chain length is important for shogaols in protecting neuronal cells from beta-amyloid insult

Bioorg Med Chem Lett. 2004 Mar 8;14(5):1287-9. doi: 10.1016/j.bmcl.2003.12.041.

Abstract

Ten shogaols were synthesized to evaluate the importance of the side-chain length in protecting cells from betaA(1-42) insult using PC12 rat pheochromocytoma and IMR-32 human neuroblastoma cells. The compounds cell protectivity against betaA insult was demonstrated using 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) reduction assay. The efficacy of cell protection from betaA insult by these shogaols was shown to improve as the length of the side chain increase.

MeSH terms

  • Amyloid beta-Peptides / toxicity*
  • Animals
  • Catechols / chemistry*
  • Catechols / pharmacology
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Cell Survival / physiology
  • Humans
  • Neurons / drug effects*
  • Neurons / physiology
  • Neuroprotective Agents / chemistry*
  • Neuroprotective Agents / pharmacology
  • PC12 Cells
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology
  • Rats
  • Structure-Activity Relationship

Substances

  • Amyloid beta-Peptides
  • Catechols
  • Neuroprotective Agents
  • Plant Extracts
  • shogaol