Hematopoietic stem cell transplantation using umbilical cord blood progenitors: review of current clinical results

Bone Marrow Transplant. 2004 Apr;33(7):675-90. doi: 10.1038/sj.bmt.1704405.


Umbilical cord blood (CB) has been rapidly established as an alternative source of stem cells to bone marrow for allogeneic-related and unrelated hematopoietic transplantation. To date, almost 70 000 CB units are available for transplantation and more than 2000 CB transplants (CBT) have been performed, mostly in children, for the treatment of a variety of malignant and nonmalignant conditions. Considerable experience has been rapidly accumulated in this field and many aspects of CBT have been elucidated, while other questions remain unresolved. A concise review of the clinical results achieved after related and unrelated CBT is presented and discussed.

Publication types

  • Review

MeSH terms

  • Adult
  • Child
  • Cord Blood Stem Cell Transplantation / adverse effects
  • Cord Blood Stem Cell Transplantation / methods*
  • Graft vs Host Disease
  • Hematopoiesis
  • Hematopoietic Stem Cell Transplantation / adverse effects
  • Hematopoietic Stem Cell Transplantation / methods
  • Humans
  • Transplantation Immunology
  • Treatment Outcome