Association of a functional 1019C>G 5-HT1A receptor gene polymorphism with panic disorder with agoraphobia

Int J Neuropsychopharmacol. 2004 Jun;7(2):189-92. doi: 10.1017/S1461145703004061. Epub 2004 Feb 25.


Panic disorder is a common anxiety disorder which frequently co-occurs with agoraphobia. A functional promoter polymorphism in the serotonin receptor 1A (5-HT1A) gene has been found to be associated with major depression as well as anxiety- and depression-related personality traits. We investigated a possible association between this 5-HT1A gene promoter polymorphism and panic disorder by genotyping the 1019C>G single nucleotide polymorphism in 134 panic-disorder patients with and without agoraphobia and matched 134 controls. In our sample no significant evidence of allelic association in the combined panic-disorder group was found. However, our results show a significant association with the G allele in patients with panic disorder with agoraphobia (p=0.03, n=101). In conclusion, our findings do not support a major contribution of this polymorphism to the pathogenesis of panic disorder, but provide evidence for a possible role in the subgroup with agoraphobia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Agoraphobia / genetics*
  • Agoraphobia / psychology*
  • Alleles
  • DNA / genetics
  • DNA Primers
  • Female
  • Gene Frequency
  • Genotype
  • Humans
  • Logistic Models
  • Male
  • Middle Aged
  • Panic Disorder / genetics*
  • Panic Disorder / psychology*
  • Polymorphism, Genetic / genetics*
  • Promoter Regions, Genetic / genetics
  • Psychiatric Status Rating Scales
  • Receptor, Serotonin, 5-HT1A / genetics*
  • Reverse Transcriptase Polymerase Chain Reaction


  • DNA Primers
  • Receptor, Serotonin, 5-HT1A
  • DNA