EG-VEGF and Bv8: a novel family of tissue-restricted angiogenic factors

Biochim Biophys Acta. 2004 Mar 4;1654(1):69-78. doi: 10.1016/j.bbcan.2003.07.001.


A novel family of angiogenic mitogens have been recently characterized. Endocrine gland-derived vascular endothelial growth factor (EG-VEGF), and the mammalian homologue of Bombina variegata peptide 8 (Bv8), are two highly related endothelial cell mitogens and chemotactic factors with restricted expression profiles and selective endothelial cell activity. These peptides share two cognate G-protein coupled receptors. The expression of human EG-VEGF occurs predominantly in steroidogenic glands. Consistent with such an expression pattern, the human EG-VEGF gene promoter has a potential binding site for steroidogenic factor (SF)-1, a pivotal element for steroidogenic-specific transcription. In the human ovary, the expression of EG-VEGF is temporally and spatially complementary to the expression of VEGF-A, both in the follicular and in the luteal phase, suggesting complementary and coordinated roles of these molecules in ovarian angiogenesis. Also, EG-VEGF expression correlates with vascularity in the polycystic ovary syndrome, a leading cause of infertility. Bv8 expression is mainly restricted to the testis. The identification of these tissue-selective angiogenic factors raises the possibility that other secreted molecules with selectivity for the endothelium of other organs exist.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Cloning, Molecular
  • Endothelium, Vascular / drug effects
  • Female
  • Follicular Phase
  • Gastrointestinal Hormones / biosynthesis
  • Gastrointestinal Hormones / genetics*
  • Gastrointestinal Hormones / pharmacology
  • Gene Expression Regulation
  • Humans
  • Leydig Cells / metabolism
  • Male
  • Molecular Sequence Data
  • Neovascularization, Pathologic / metabolism
  • Neuropeptides / biosynthesis
  • Neuropeptides / genetics*
  • Neuropeptides / pharmacology
  • Ovary / metabolism
  • Polycystic Ovary Syndrome / metabolism
  • RNA, Messenger / biosynthesis
  • Sequence Alignment
  • Vascular Endothelial Growth Factor, Endocrine-Gland-Derived / biosynthesis
  • Vascular Endothelial Growth Factor, Endocrine-Gland-Derived / genetics*
  • Vascular Endothelial Growth Factor, Endocrine-Gland-Derived / pharmacology


  • Gastrointestinal Hormones
  • Neuropeptides
  • PROK2 protein, human
  • RNA, Messenger
  • Vascular Endothelial Growth Factor, Endocrine-Gland-Derived