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Comparative Study
. 2003 Dec;125(6):794-7.
doi: 10.1115/1.1632522.

Kinetics Study of Endogenous Heat Shock Protein 70 Expression

Comparative Study

Kinetics Study of Endogenous Heat Shock Protein 70 Expression

Sihong Wang et al. J Biomech Eng. .


The purpose of this study was to determine the kinetics of HSP70 expression in response to mild thermal stress. The rationale is to produce a basis for design of optimal heating methods to induce HSP70 expression for preconditioning in cardiac surgery. Bovine aortic endothelial cells were heated at 42 degrees C for 0.5 to 5 hours followed by 37 degrees C recovery for 1 to 48 hours. Quantitative analysis of western blot results showed HSP70 expression kinetics is a coupled function of heating temperature and time and of post-heating duration. Bimodal HSP70 expression kinetics were identified which may be an important cause of the "second window of protection" observed by other researchers.

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