Actin polymerization: riding the wave

Curr Biol. 2004 Feb 3;14(3):R109-11.

Abstract

WAVE/SCAR has long been known to activate the actin-nucleating Arp2/3 complex in a Rac-dependent manner. Recent biochemical and genetic studies have revealed important roles for four WAVE-associated proteins in regulating WAVE function.

Publication types

  • Review

MeSH terms

  • Actins / biosynthesis*
  • Adaptor Proteins, Signal Transducing
  • Animals
  • Microfilament Proteins / metabolism*
  • Models, Biological*
  • Oncogene Proteins / metabolism
  • Signal Transduction*
  • Wiskott-Aldrich Syndrome Protein Family
  • rac GTP-Binding Proteins / metabolism

Substances

  • Actins
  • Adaptor Proteins, Signal Transducing
  • Microfilament Proteins
  • Nck protein
  • Oncogene Proteins
  • Wiskott-Aldrich Syndrome Protein Family
  • rac GTP-Binding Proteins