Overgrowth and pruning of dendrites in adult rats recovering from neocortical damage

Brain Res. 1992 May 22;581(1):156-60. doi: 10.1016/0006-8993(92)90356-e.


Unilateral lesions to the forelimb representation (FL) area of the rat sensorimotor cortex caused a time-dependent increase in the dendritic arborization of layer V pyramidal neurons in the contralateral homotopic cortex. The increase in arborization was maximum at 2-3 weeks after the lesion, following which there was a partial reduction in dendritic branching. These neural morphological changes may be related to post-lesion behavioral changes in the use of the forelimbs.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Analysis of Variance
  • Animals
  • Choice Behavior / physiology*
  • Dendrites / physiology*
  • Male
  • Neuronal Plasticity / physiology*
  • Rats
  • Somatosensory Cortex / injuries
  • Somatosensory Cortex / physiology*