Neurobiology: New Connections Between Integrins and Axon Guidance

Curr Biol. 2004 Feb 3;14(3):R121-3.

Abstract

Axon guidance molecules such as netrins, semaphorins, Slits and ephrins provide the cues required for accurate patterning of axonal projections in the nervous system. Recent reports have described multiple paradigms by which these molecules interact with integrin adhesion receptors in and outside the neuronal tissues.

Publication types

  • Review

MeSH terms

  • Axons / physiology*
  • Cell Movement / physiology*
  • Drosophila Proteins*
  • Ephrins / metabolism
  • Integrins / metabolism
  • Integrins / physiology*
  • Nerve Growth Factors / metabolism
  • Nerve Tissue Proteins / metabolism
  • Netrin-1
  • Semaphorins / metabolism*
  • Semaphorins / physiology
  • Tumor Suppressor Proteins

Substances

  • Drosophila Proteins
  • Ephrins
  • Integrins
  • Nerve Growth Factors
  • Nerve Tissue Proteins
  • Semaphorins
  • Tumor Suppressor Proteins
  • sli protein, Drosophila
  • Netrin-1