Regulation of Notch Signaling Activity

Curr Biol. 2004 Feb 3;14(3):R129-38.

Abstract

Cell-cell signalling mediated by the receptor Notch is used widely across the metazoans to determine cell fate and regulate pattern formation. Notch signals via a conserved regulated intramembrane proteolysis. Recent analyses of the cell biology of the Notch receptor have identified several fundamental mechanisms that contribute to regulate Notch signaling activity in space and time.

Publication types

  • Review

MeSH terms

  • Amyloid Precursor Protein Secretases
  • Calcium-Binding Proteins
  • Cell Communication / physiology*
  • Cell Differentiation / physiology
  • Drosophila Proteins / metabolism
  • Endocytosis / physiology
  • Endopeptidases / metabolism
  • Fucosyltransferases / metabolism
  • Intercellular Signaling Peptides and Proteins
  • Jagged-1 Protein
  • Juvenile Hormones / metabolism
  • Ligands
  • Membrane Proteins / metabolism*
  • Membrane Proteins / physiology
  • Models, Biological*
  • Protein Structure, Tertiary
  • Receptors, Cell Surface / metabolism*
  • Receptors, Cell Surface / physiology
  • Receptors, Notch
  • Serrate-Jagged Proteins
  • Signal Transduction / physiology*

Substances

  • Calcium-Binding Proteins
  • Drosophila Proteins
  • Intercellular Signaling Peptides and Proteins
  • Jagged-1 Protein
  • Juvenile Hormones
  • Ligands
  • Membrane Proteins
  • Receptors, Cell Surface
  • Receptors, Notch
  • Ser protein, Drosophila
  • Serrate-Jagged Proteins
  • numb protein, Drosophila
  • Fucosyltransferases
  • O-fucosyltransferase 1, Drosophila
  • Amyloid Precursor Protein Secretases
  • Endopeptidases