Excitatory amino acids and the actions of cocaine

Brain Res. 1992 Jun 5;582(1):143-6. doi: 10.1016/0006-8993(92)90329-8.

Abstract

Antagonists of the N-methyl-D-aspartate (NMDA) type of excitatory amino acid (EAA) receptors blocked cocaine-induced stereotypy, locomotor stimulation and convulsions. These effects in general appear to involve selectively NMDA type of receptors. The results suggest that NMDA-activated systems are an integral component in the reaction sequences involved in the expression of several behavioral effects of cocaine.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Caffeine / pharmacology
  • Cocaine / pharmacology*
  • Dextromethorphan / pharmacology
  • Dizocilpine Maleate / pharmacology
  • Haloperidol / pharmacology
  • Male
  • Mice
  • Mice, Inbred Strains
  • Motor Activity / drug effects*
  • N-Methylaspartate / antagonists & inhibitors*
  • N-Methylaspartate / pharmacology
  • Pipecolic Acids / pharmacology
  • Quinoxalines / pharmacology
  • Rats
  • Rats, Inbred Strains
  • Seizures / chemically induced
  • Seizures / physiopathology
  • Stereoisomerism
  • Stereotyped Behavior / drug effects*

Substances

  • Pipecolic Acids
  • Quinoxalines
  • Caffeine
  • selfotel
  • FG 9041
  • N-Methylaspartate
  • Dizocilpine Maleate
  • Dextromethorphan
  • Cocaine
  • Haloperidol