Abstract
Antagonists of the N-methyl-D-aspartate (NMDA) type of excitatory amino acid (EAA) receptors blocked cocaine-induced stereotypy, locomotor stimulation and convulsions. These effects in general appear to involve selectively NMDA type of receptors. The results suggest that NMDA-activated systems are an integral component in the reaction sequences involved in the expression of several behavioral effects of cocaine.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Caffeine / pharmacology
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Cocaine / pharmacology*
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Dextromethorphan / pharmacology
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Dizocilpine Maleate / pharmacology
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Haloperidol / pharmacology
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Male
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Mice
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Mice, Inbred Strains
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Motor Activity / drug effects*
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N-Methylaspartate / antagonists & inhibitors*
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N-Methylaspartate / pharmacology
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Pipecolic Acids / pharmacology
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Quinoxalines / pharmacology
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Rats
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Rats, Inbred Strains
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Seizures / chemically induced
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Seizures / physiopathology
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Stereoisomerism
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Stereotyped Behavior / drug effects*
Substances
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Pipecolic Acids
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Quinoxalines
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Caffeine
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selfotel
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FG 9041
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N-Methylaspartate
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Dizocilpine Maleate
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Dextromethorphan
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Cocaine
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Haloperidol