Paxdaphnidines A and B, novel penta- and tetracyclic alkaloids from Daphniphyllum paxianum

J Org Chem. 2004 Mar 5;69(5):1726-9. doi: 10.1021/jo035592t.

Abstract

Two novel alkaloids, paxdaphnidine A (1) with a unique pentacyclic skeleton and paxdaphnidine B (2) with an uncommon tetracyclic skeleton, were isolated from the stems and leaves of Daphniphyllum paxianum. Their structures were established by spectral methods, especially two-dimensional NMR techniques ((1)H-(1)H COSY, HSQC, HMBC, and NOESY).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / chemistry
  • Alkaloids / isolation & purification*
  • Carbohydrate Conformation
  • Heterocyclic Compounds, 4 or More Rings / chemistry
  • Heterocyclic Compounds, 4 or More Rings / isolation & purification*
  • Magnetic Resonance Spectroscopy
  • Models, Molecular
  • Molecular Structure
  • Plant Leaves / chemistry
  • Plant Stems / chemistry
  • Saxifragaceae / chemistry*

Substances

  • Alkaloids
  • Heterocyclic Compounds, 4 or More Rings
  • paxdaphnidine A
  • paxdaphnidine B