Atopic disorders and risk of childhood-onset type 1 diabetes in individuals

Clin Exp Allergy. 2004 Feb;34(2):201-6. doi: 10.1111/j.1365-2222.2004.01864.x.


Background: Data on the relationship between Th2-biased atopic disorders and Th1-biased autoimmune diseases such as type 1 diabetes are conflicting. Many studies have not defined the time sequence of disease appearance, and few have investigated the role of candidate risk factors.

Objective: The objective was to investigate whether the presence of parents' report of physician-diagnosed atopic disorders is lower among cases of type 1 diabetes before diagnosis, as compared with population-based control subjects, and whether this may be explained by candidate risk factors such as day-care attendance, breastfeeding habits, and perinatal factors.

Methods: We designed a population-based case-control study in Norway with 545 cases of childhood-onset type 1 diabetes and 1668 control subjects. Families were contacted by mail, and they completed a questionnaire on physician-diagnosed atopic eczema, allergic rhino-conjunctivitis and asthma, and other relevant factors. Data on birth order, maternal age at delivery, birth weight, gestational age, pre-eclampsia, and caesarean section were obtained from the Medical Birth Registry of Norway by record linkage.

Results: Atopic eczema was inversely associated with risk of type 1 diabetes, odds ratio=0.55 (95% confidence interval 0.35-0.87) after adjustment for age, sex, maternal education, day-care attendance, duration of exclusive breastfeeding, and perinatal factors. Allergic rhino-conjunctivitis and asthma were not significantly associated with type 1 diabetes.

Conclusions: Atopic eczema was associated with a lower risk of type 1 diabetes, independent of a number of candidate risk factors, suggesting that it may confer partial protection against type 1 diabetes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Asthma / complications
  • Breast Feeding
  • Case-Control Studies
  • Child
  • Child Day Care Centers
  • Conjunctivitis, Allergic / complications
  • Dermatitis, Allergic Contact / complications
  • Diabetes Mellitus, Type 1 / immunology*
  • Female
  • Humans
  • Hypersensitivity / complications*
  • Logistic Models
  • Male
  • Norway
  • Odds Ratio
  • Pregnancy
  • Rhinitis / complications
  • Risk