Neuroenergetics: calling upon astrocytes to satisfy hungry neurons

Neuroscientist. 2004 Feb;10(1):53-62. doi: 10.1177/1073858403260159.


Classical neuroenergetics states that glucose is the exclusive energy substrate of brain cells and its full oxidation provides all the necessary energy to support brain function. Recent data have revealed a more intricate picture in which astrocytes play a key role in supplying lactate as an additional energy substrate in register with glutamatergic activity.

Publication types

  • Review

MeSH terms

  • Animals
  • Astrocytes / metabolism*
  • Energy Metabolism / physiology*
  • Humans
  • Neurodegenerative Diseases / metabolism*
  • Neurons / metabolism*