The role of the arginine-nitric oxide pathway in the pathogenesis of bipolar affective disorder

Eur Arch Psychiatry Clin Neurosci. 2004 Feb;254(1):43-7. doi: 10.1007/s00406-004-0453-x.

Abstract

There is a reciprocal regulation of arginase and nitric oxide synthase (NOS) in L-arginine-metabolizing pathways. Nitric oxide (NO) may be involved in some psychiatric disorders like schizophrenia, depression and bipolar affective disorder (BPAD). To our knowledge, there is no study in the literature in which the role of arginase, an important part of the arginine regulatory system affecting NOS activity, was investigated in BPAD. This study aims to investigate arginase, manganese (Mn) and total nitrite levels (a metabolite of NO) and their relationship to the arginine-NO pathway in patients with BPAD. Arginase activities, Mn and total nitrite levels were measured in plasma from forty-three patients with BPAD (Type one) and thirty-one healthy control subjects. Plasma arginase activities and Mn were found to be significantly lower and total nitrite level higher in patients with BPAD compared with controls. Our results suggest that the arginine-NO pathway is involved in the pathogenesis of BPAD.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Analysis of Variance
  • Arginine / blood*
  • Bipolar Disorder / blood*
  • Case-Control Studies
  • Diagnostic and Statistical Manual of Mental Disorders
  • Female
  • Humans
  • Male
  • Manganese / blood
  • Middle Aged
  • Nitric Oxide / blood*
  • Nitrites / blood
  • Sex Factors

Substances

  • Nitrites
  • Nitric Oxide
  • Manganese
  • Arginine